Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Shape-dependent disassembly of polygonal microparticles in two dimensions.

Soft matter·2026
Same author

Particle Shape Modulates the Function of Adoptive Macrophage Transfers.

Advanced healthcare materials·2025
Same author

Ionic Liquid-Mediated Delivery of Ruxolitinib to Skin Using an Adhesive Topical Hydrogel System.

Advanced healthcare materials·2025
Same author

Soft Extrudable Dendritic Particles with Nanostructured Tendrils for Local Adhesion and Drug Release to Bladder Cancers.

Advanced materials (Deerfield Beach, Fla.)·2025
Same author

Precise surface patches on active particles of arbitrary shape through microstenciling.

Nature communications·2025
Same author

Technology Roadmap of Micro/Nanorobots.

ACS nano·2025

Related Experiment Video

Updated: Mar 27, 2026

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice
11:32

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

14.5K

Siphon-based multichannel acoustofluidic separator for rapid and multiplexed biomolecule detection.

Cooper P Thome1, Creighton T Tisdale1, C Wyatt Shields1,2,3,4

  • 1Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, USA.

Device
|March 25, 2026
PubMed
Summary

Researchers developed a 3D-printed multichannel acoustic separator using microparticles to simplify biomarker isolation from complex fluids. This innovative device significantly reduces processing time for biological sensing applications.

More Related Videos

Microfluidic Acoustophoresis for Flowthrough Separation of Gram-Negative Bacteria using Aptamer Affinity Beads
06:08

Microfluidic Acoustophoresis for Flowthrough Separation of Gram-Negative Bacteria using Aptamer Affinity Beads

Published on: October 17, 2022

3.1K
Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
11:54

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

9.9K

Related Experiment Videos

Last Updated: Mar 27, 2026

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice
11:32

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

14.5K
Microfluidic Acoustophoresis for Flowthrough Separation of Gram-Negative Bacteria using Aptamer Affinity Beads
06:08

Microfluidic Acoustophoresis for Flowthrough Separation of Gram-Negative Bacteria using Aptamer Affinity Beads

Published on: October 17, 2022

3.1K
Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
11:54

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

9.9K

Area of Science:

  • Biotechnology
  • Biomedical Engineering
  • Analytical Chemistry

Background:

  • Current biological sensing methods involve complex, time-consuming workflows for biomolecule isolation and detection.
  • Existing instruments are often cumbersome, limiting accessibility and user-friendliness in biological sample preparation.

Purpose of the Study:

  • To present a novel multichannel acoustic separator designed to simplify and accelerate biomarker isolation from complex biological fluids.
  • To demonstrate a user-friendly and accessible approach for biospecific particle enrichment and detection.

Main Methods:

  • Development of a 3D-printed multichannel acoustic separator with 12 acoustofluidic trapping channels.
  • Utilized biospecific and acoustically responsive microparticles for targeted biomarker capture.
  • Employed a semi-continuous siphon for fluid flow, eliminating the need for external pumps.

Main Results:

  • Successfully purified three distinct biomolecules in both individual and multiplexed formats.
  • Achieved purification of immunoglobulin A (IgA) from whole blood within approximately 70 minutes.
  • Demonstrated effective isolation of biospecific particles from contaminants using acoustofluidic trapping.

Conclusions:

  • The multichannel acoustic separator offers a simplified and efficient workflow for biomarker isolation and detection.
  • The 3D-printed, pump-free system enhances accessibility and reduces processing time in biological sensing.
  • This technology holds promise for rapid and sensitive biomarker analysis in various complex fluid samples.