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Updated: Jul 10, 2026

Isolation, Identification, and Purification of Murine Thymic Epithelial Cells
Published on: August 8, 2014
Steroid receptors in the myasthenic thymus
M M Brentani1, V R Martins, P E Marchiori
1Departamento de Clínica Médica, Faculdade de Medicina, Universidade de São Paulo, Brasil.
Abstract:
Estrogen (ER), progesterone (PR), androgen (AR) and glucocorticoid receptors (GR) were evaluated in thymus cytosols from 15 myasthenia gravis (MG) patients, using a dextran charcoal assay. ER was found in 40%, PR and AR in 53% and GR in 100% of MG thymi. Competition studies demonstrated steroid specificity for all receptors. Mean ER and AR levels in MG thymi were higher than those in the thymi of 4 control children. Female patients have higher AR titers. Myasthenic thymi presented lower GR values than in normal controls: Differences in steroid receptor content observed in the MG thymus as compared to the child thymus may reflect variations in cell populations.
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