[Morphologic measurement for diagnosis of gastric dysplasia]

Gastric dysplasia is a very important precancerous change recognized only by histological examination. The objective indexes of diagnosing the dysplastic change are hardly established. It is desirable to translate enumeration data of histopathology into measurement data in order to obtain objective measurement criteria for the diagnosis of gastric dysplasia. In this paper, three measurement indexes N/C, P1/D1 and P2/D2 are proposed. N/C represents the ratio of nucleus and cytoplasm, showing the cellular atypia. P1/D1 represents the ratio of outer perimeter of the measured glandular tube and diameter of an equivalent circle, showing the structural atypia. P2/D2 is the ratio of perimeter of the irregular shape by tracing the end of the nuclei near the lumen of the tube and diameter of an equivalent circle, showing both cellular and structural atypia. The results indicate that these three measurement criteria can be taken as the objective indexes for diagnosing gastric dysplasia and predicting its potential malignancy.