[Effect and toxicity of entrapped polysiloxane 5-Fu polycondensate]

Entrapped 5-Fu polysiloxane polycondensate (DMS-Fu) and equivalent doses of 5-Fu were tested on S-180 mice. At the dose of 100 mg/kg, the inhibition potency of these two compounds on tumor was similar, but the inhibition on the body weight was more marked in 5-Fu treated mice. At the dose of 250 mg/kg, all mice treated with 5-Fu died of toxicity but the mice treated with DMS-Fu survived and showed no obvious toxic effect. At the dose of 150-200 mg/kg, the peripheral white blood cells and the bone marrow nucleated cells of 5-Fu treated mice were seriously reduced, which lasted for several days before recovery. In the DMS-Fu group, the inhibition was mild.