[Endocrine changes in experimental hypothalamic obesity in rats]

Hypothalamic adiposity in rats developing in bilateral electrolytic damage of the ventromedial hypothalamus is characterized by a marked activation of the insular apparatus of the pancreas, enhanced biosynthesis and secretion of the somatotropin by the hypophysis, reduction of the thyrotropic function of the hypophysis and functional activity of the thyroid gland with a disturbed metabolism of the thyroid hormones in target tissues, unchanged or reduced glucocorticoid function of the adrenal glands, intensified lipogenesis, reduction of the content of cyclic 3',5'-adenosinmonophosphate in a number of organs and tissues.