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Updated: Oct 20, 2025

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide
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Management of Pediatric Strokes With Alteplase (Tissue Plasminogen Activator)

Asia Filatov1, Jaime Alvarez2, Jessica Seibert3

  • 1Neurology, Florida Atlantic University, Boca Raton, USA.

Cureus
|September 16, 2021
PubMed

Insights

Pediatric ischemic stroke is rare but treatable with thrombolysis and thrombectomy. This case highlights challenges in diagnosing and treating young patients with acute ischemic stroke, emphasizing the need for specialized care.

Area of Science:

  • Neurology
  • Pediatrics
  • Vascular Medicine

Background:

  • Acute ischemic stroke is uncommon in children.
  • Pediatric stroke patients can receive advanced treatments like intravenous thrombolysis and mechanical thrombectomy.
  • Challenges exist in timely diagnosis and treatment due to stroke rarity and a shortage of pediatric neurologists.

Observation:

  • A 16-year-old female presented with symptoms of an acute ischemic stroke.
  • The patient was evaluated and treated within an adult comprehensive stroke program.

Findings:

  • The case demonstrates the complexities of managing pediatric acute ischemic stroke.
  • Successful integration of a pediatric patient into an adult stroke care pathway was achieved.

Implications:

  • Highlights the need for accessible pediatric stroke expertise.
  • Suggests potential models for managing rare pediatric neurological emergencies in adult-centric facilities.
  • Underscores the importance of early recognition and intervention for improved outcomes in pediatric stroke.

Keywords:
alteplasepediatric strokestroketissue plasminogen activator (tpa)tpa

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