Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 5, 2026

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation

Published on: April 13, 2011

Islet Transplantation in the UK.

P R V Johnson¹

¹Director of the Oxford DRWF Islet Isolation Facility, Director of the Islet Transplant Programme, and Chair of the NHSBT UK Islet Steering Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Oxford, UK.

Cellr4-- Repair, Replacement, Regeneration, & Reprogramming

|September 16, 2021

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effect of Etanercept Concentration on Human Islet Integrity.

Transplantation proceedings·2017

Same author

Hypoxia-Induced Damage in Human Islets Is Reduced With the Use of Mesenchymal Stem Cell-Preconditioned Medium.

Transplantation proceedings·2017

Same author

Key Matrix Proteins Within the Pancreatic Islet Basement Membrane Are Differentially Digested During Human Islet Isolation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016

Same author

Contemporary management and outcomes for infants born with oesophageal atresia.

The British journal of surgery·2013

Same author

Perfluorocarbon emulsions prevent hypoxia of pancreatic β-cells.

Cell transplantation·2011

Same author

Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?

Diabetes, obesity & metabolism·2011

Same journal

Islet transplantation in Italy.

CellR4-- repair, replacement, regeneration, & reprogramming·2021

Same journal

Commentary: Not reimbursing islet transplantation creates discrimination against patients with type 1 diabetes.

CellR4-- repair, replacement, regeneration, & reprogramming·2021

Same journal

MESENCHYMAL STEM CELLS.

CellR4-- repair, replacement, regeneration, & reprogramming·2021

Same journal

Can high-dose omega-3 fatty acids and high-dose vitamin D3 (cholecalciferol) prevent type 1 diabetes and sustain preservation of beta-cell function after disease onset?

CellR4-- repair, replacement, regeneration, & reprogramming·2021

Same journal

Improving the regulatory framework for cell therapy does not equate to deregulation.

CellR4-- repair, replacement, regeneration, & reprogramming·2021

Same journal

Umbilical Cord-derived Mesenchymal Stem Cells for COVID-19 Patients with Acute Respiratory Distress Syndrome (ARDS).

CellR4-- repair, replacement, regeneration, & reprogramming·2021

See all related articles

The UK Islet Transplant Programme has advanced, demonstrating the success of beta-cell therapies. It is recommended that other nations establish similar, fully funded islet cell programs for broader patient access.

Area of Science:

Endocrinology
Transplantation Immunology
Regenerative Medicine

Background:

The UK Islet Transplant Programme has progressed significantly.
Beta-cell replacement therapy offers a potential cure for type 1 diabetes.
Current challenges include donor organ availability and long-term graft survival.

Purpose of the Study:

To review the development and current status of the UK Islet Transplant Programme.
To advocate for the establishment of similar fully funded beta-cell programs internationally.
To highlight the potential of islet transplantation as a viable treatment option.

Main Methods:

This is a commentary, not an experimental study.
It synthesizes existing data and clinical experience from the UK programme.

Keywords:

Beta-cell replacement Islet transplantation Pancreas allocation United Kingdom

More Related Videos

Inguinal Subcutaneous White Adipose Tissue (ISWAT) Transplantation Model of Murine Islets

Inguinal Subcutaneous White Adipose Tissue (ISWAT) Transplantation Model of Murine Islets

Published on: February 16, 2020

Fat-Covered Islet Transplantation Using Epididymal White Adipose Tissue

Fat-Covered Islet Transplantation Using Epididymal White Adipose Tissue

Published on: May 25, 2021

Related Experiment Videos

Last Updated: Jul 5, 2026

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation

Published on: April 13, 2011

Inguinal Subcutaneous White Adipose Tissue (ISWAT) Transplantation Model of Murine Islets

Inguinal Subcutaneous White Adipose Tissue (ISWAT) Transplantation Model of Murine Islets

Published on: February 16, 2020

Fat-Covered Islet Transplantation Using Epididymal White Adipose Tissue

Fat-Covered Islet Transplantation Using Epididymal White Adipose Tissue

Published on: May 25, 2021

It draws upon the author's expertise in islet transplantation.

Main Results:

The UK Islet Transplant Programme has achieved notable successes.
The commentary provides a comprehensive overview of the programme's evolution.
Key milestones and outcomes are discussed.

Conclusions:

The UK model provides a strong foundation for international adoption.
Fully funded beta-cell programs are crucial for advancing islet transplantation globally.
Widespread implementation could significantly improve outcomes for patients with type 1 diabetes.