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Updated: Oct 20, 2025

Fat-Covered Islet Transplantation Using Epididymal White Adipose Tissue
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Islet transplantation in Italy.

F Bertuzzi1

  • 1SSD Diabetology, Niguarda Hospital, Milan, Italy.

Cellr4-- Repair, Replacement, Regeneration, & Reprogramming
|September 16, 2021
PubMed
Summary
This summary is machine-generated.

Italy performs islet transplantation for type 1 diabetes mellitus patients. However, current reimbursement structures inadequately cover islet isolation and transplantation costs, despite significant program activity.

Keywords:
Islet transplantationPancreas procurementType 1 diabetes

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Area of Science:

  • Endocrinology
  • Transplantation Surgery
  • Health Economics

Background:

  • Milan hosts Italy's two primary islet transplant centers: San Raffaele Scientific Institute and Niguarda Hospital.
  • By 2018, approximately 200 patients with type 1 diabetes mellitus underwent islet allotransplantation, with around 100 receiving islet auto-transplantation post-pancreatectomy in Italy.

Purpose of the Study:

  • To highlight the significant volume of islet transplantation procedures in Italy.
  • To address the financial challenges associated with islet isolation and transplantation due to inadequate reimbursement.

Main Methods:

  • Analysis of islet transplantation activity in Italy up to 2018.
  • Review of current reimbursement policies, specifically Diagnosis-related group (DRG) coverage.

Main Results:

  • Substantial islet transplantation activity exists in Milanese centers.
  • Existing Diagnosis-related group reimbursement fails to cover the full costs of islet isolation and transplantation.

Conclusions:

  • Despite high procedural volumes, a dedicated reimbursement fee for islet isolation is lacking in Italy.
  • Current DRG-based reimbursement is insufficient to cover the comprehensive costs of islet transplantation, posing financial challenges.