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Related Concept Videos

Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

434
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
434

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Related Experiment Video

Updated: Oct 20, 2025

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
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DSM-5 Adult Attention-Deficit/Hyperactivity Disorder: Sex Differences in EEG Activity.

Franca E Dupuy1, Adam R Clarke2, Robert J Barry1

  • 1Brain & Behaviour Research Institute and School of Psychology, University of Wollongong, Wollongong, 2522, Australia.

Applied Psychophysiology and Biofeedback
|September 16, 2021
PubMed
Summary
This summary is machine-generated.

Attention-Deficit/Hyperactivity Disorder (AD/HD) impacts male and female brain activity differently. Males with AD/HD show distinct EEG patterns, particularly in theta and beta waves, unlike females with the condition.

Keywords:
AdultsAttention-deficit/hyperactivity disorderDSM-5EEGFemales: Sex differences

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Electroencephalography (EEG)

Background:

  • Attention-Deficit/Hyperactivity Disorder (AD/HD) is a prevalent neurodevelopmental disorder.
  • Existing research on AD/HD neurobiology has predominantly focused on male subjects.
  • Sex-based differences in AD/HD presentation and underlying mechanisms require further investigation.

Purpose of the Study:

  • To investigate sex differences in electroencephalogram (EEG) patterns in adults diagnosed with AD/HD.
  • To compare EEG characteristics between males and females with AD/HD and their respective control groups.
  • To identify specific EEG markers that differentiate AD/HD presentation in males versus females.

Main Methods:

  • Recruitment of 16 males and 16 females with AD/HD (DSM-5 criteria) and age/sex-matched controls.
  • Recording of eyes-closed resting EEG data from 19 electrode sites.
  • Analysis of EEG data using Fast Fourier Transform to obtain power spectrum estimates and theta/beta ratios across cortical regions.

Main Results:

  • Males with AD/HD exhibited globally reduced absolute beta power and elevated relative theta power compared to male controls.
  • A significantly larger theta/beta ratio was observed in males with AD/HD.
  • No global EEG differences were found between females with and without AD/HD, but significant group interactions highlighted sex-specific EEG alterations.

Conclusions:

  • AD/HD is associated with distinct EEG alterations in males, characterized by changes in theta and beta wave activity.
  • The neurophysiological impact of AD/HD appears to differ significantly between sexes.
  • Findings underscore the necessity for sex-specific research and diagnostic considerations in AD/HD populations, particularly for females.