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Updated: Oct 20, 2025

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Published on: March 30, 2018

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Takes one to B1a: Dismantling the origin of mantle cell lymphoma

Anna E Beaudin

    The Journal of Experimental Medicine
    |September 16, 2021
    PubMed

    Insights

    Researchers developed a new mouse model for mantle cell lymphoma (MCL) by overexpressing cyclin D2. This model identifies fetal-derived B1a cells as the likely cell of origin for MCL, aiding therapeutic discovery.

    Area of Science:

    • Hematology
    • Oncology
    • Molecular Biology

    Background:

    • Therapeutic discovery for mantle cell lymphoma (MCL) is challenging due to the absence of accurate preclinical models.
    • Existing models do not fully replicate the complexity of human MCL.

    Purpose of the Study:

    • To establish a novel preclinical mouse model for mantle cell lymphoma (MCL).
    • To identify the cell of origin for MCL.
    • To facilitate the development of new MCL therapies.

    Main Methods:

    • Overexpression of cyclin D2 in a mouse model.
    • Analysis of B-cell populations and lymphoma development.
    • Identification of the cell of origin through lineage tracing and characterization.

    Main Results:

    • A novel mouse model of MCL was successfully established, driven by cyclin D2 overexpression.
    • Fetal-derived B1a cells were identified as the putative cell of origin for MCL in this model.
    • The model recapitulates key features of human MCL, enabling further study.

    Conclusions:

    • The developed mouse model is a valuable tool for studying MCL pathogenesis and testing novel therapeutics.
    • Understanding the cell of origin (B1a cells) provides new insights into MCL development.
    • This research paves the way for improved therapeutic strategies for mantle cell lymphoma.

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