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Patient With Hemophilia A Undergoing Consecutive Coronary Bypass and Live Donor Liver Transplantation: A Case Report
Cihan Karatas1, Altan Alim1, Ismail Tirnova1
1Department of Organ Transplantation, Koc University Hospital, Istanbul, Turkey.
Insights
Liver transplantation is a rare but viable option for patients with hemophilia A and cirrhosis. This case study shows successful liver transplant outcomes without complications or changes in factor VIII levels.
Area of Science:
- Hepatology
- Transplantation Surgery
- Hematology
Background:
- Liver transplantation is rarely performed in patients with hemophilia due to cirrhosis.
- Limited literature exists on the outcomes of liver transplantation in this patient population.
Observation:
- A patient with hemophilia A presented with coronary artery disease and cryptogenic cirrhosis with hepatocellular carcinoma.
- The patient underwent two consecutive surgeries, including a liver transplantation.
Findings:
- The patient experienced no bleeding or other complications post-liver transplantation.
- Factor VIII levels remained stable throughout the follow-up period after the liver transplant.
Implications:
- Liver transplantation can be a safe and effective treatment for selected patients with hemophilia A and end-stage liver disease.
- Successful outcomes suggest that liver transplantation does not adversely affect coagulation factor levels in hemophilia patients.
Abstract:
Liver transplantation surgery due to cirrhosis in patients with hemophilia is rare and there are limited cases in the literature. We present a case of a patient with hemophilia A who underwent 2 consecutive surgeries owing to coronary artery disease and cryptogenic cirrhosis with hepatocellular carcinoma. After these surgeries, no bleeding or other complications were seen, and the factor VIII levels have not changed since liver transplantation in the follow-up.
