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Isolation of Mouse Kidney-Resident CD8+ T cells for Flow Cytometry Analysis
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Tissue-specific differentiation of CD8+ resident memory T cells

Kun Yang1, Axel Kallies2

  • 1Department of Dermatology, Beijing Hospital, National Center of Gerontology, Beijing, China; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.

Trends in Immunology
|September 17, 2021
PubMed

CD8+ tissue-resident memory T (TRM) cells play crucial roles in defense against infections and cancer and have been implicated in autoimmune diseases such as psoriasis. In mice and humans, they exist in all nonlymphoid organs and share key characteristics across all tissues, including downregulation of tissue egress and lymph node homing pathways. However, recent studies demonstrate considerable heterogeneity across TRM cells lodged in different tissues - linked to the activity of tissue-specific molecules, including chemokines, cytokines, and transcription factors. Current work indicates that transforming growth factor (TGF)-β plays a major role in generating TRM heterogeneity at phenotypic and functional levels. Here, we review common and unique features of TRM cells in different tissues and discuss putative strategies aimed at harnessing TRM cells for site-specific protection against infectious and malignant diseases.

Keywords:
chemokine receptorsintegrinsnonlymphoid tissuetissue-resident memory T cellstranscription factorstransforming growth factor β

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