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Updated: Oct 20, 2025
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Utilization of Stop-flow Micro-tubing Reactors for the Development of Organic Transformations
Published on: January 4, 2018
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Fueling the Pipeline via Innovations in Organic Synthesis
Eric A Voight1, Stephen N Greszler1, Philip R Kym1
1Drug Discovery Science & Technology, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064-1802, United States.
ACS Medicinal Chemistry Letters
|September 17, 2021
Summary
Synthetic organic chemistry is crucial for drug discovery, enabling the creation of molecules for testing. Specialized synthesis groups accelerate innovation by overcoming accessibility challenges, leading to new drug candidates.
Area of Science:
- Synthetic organic chemistry
- Medicinal chemistry
- Pharmaceutical industry
Background:
- The design-synthesis-data cycle is central to pharmaceutical innovation.
- Medicinal chemists require synthesized molecules for data generation.
- Synthetic accessibility is a common bottleneck in drug discovery.
Purpose of the Study:
- To highlight the role of synthetic organic chemistry in accelerating drug discovery.
- To showcase the impact of Discovery Synthesis Groups (DSGs) at AbbVie.
- To illustrate how specialized synthesis teams address accessibility challenges.
Main Methods:
- Deployment of embedded Discovery Synthesis Groups (DSGs) within medicinal chemistry teams.
- Application of advanced synthetic methods and strategies by COS chemists.
- Provision of synthetic tools, scaffolds, and lead compounds to fuel drug pipelines.
Main Results:
- DSGs, like Centralized Organic Synthesis (COS), bridge the gap between discovery and process chemistry.
- COS chemists provide crucial synthetic support, accelerating innovation.
- Successful development of advanced drug candidates, including ABBV-2222 (galicaftor) and foslevodopa/foscarbidopa, with COS contributions.
Conclusions:
- Embedded synthesis groups significantly impact and accelerate the drug discovery process.
- Addressing synthetic accessibility through specialized teams is vital for pharmaceutical innovation.
- The DSG model has a proven track record of delivering advanced drug candidates for various therapeutic areas.
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