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Related Experiment Videos

Protection of foals against experimental Rhodococcus equi pneumonia by oral immunization.

J M Chirino-Trejo1, J F Prescott, J A Yager

  • 1Department of Veterinary Microbiology and Immunology, Ontario Veterinary College, University of Guelph.

Canadian Journal of Veterinary Research = Revue Canadienne De Recherche Veterinaire
|October 1, 1987
PubMed
Summary

Oral immunization with Rhodococcus equi strains protected foals against severe respiratory infection. This study demonstrates the efficacy of oral vaccination in preventing Rhodococcus equi (R. equi) disease in foals.

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Area of Science:

  • Veterinary Medicine
  • Equine Health
  • Microbiology

Background:

  • Rhodococcus equi (R. equi) is a significant cause of pneumonia in foals.
  • Effective preventative strategies against R. equi infections are crucial for equine welfare.

Purpose of the Study:

  • To evaluate the efficacy of oral immunization with Rhodococcus equi strains in protecting foals against challenge.
  • To determine if proteins associated with Congo red staining are involved in protective immunity.

Main Methods:

  • Two groups of foals were orally immunized with two different R. equi strains.
  • Control foals were non-immunized.
  • All foals were subsequently challenged via aerosol with a virulent R. equi strain.

Main Results:

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  • Oral immunization with either R. equi strain provided equal protection against challenge.
  • Immunized foals showed rapid clearance of R. equi from the lungs.
  • Control foals developed severe illness and required euthanasia.
  • Proteins associated with Congo red staining did not appear to be involved in the protective immunity.

Conclusions:

  • Oral immunization is an effective method to protect foals against severe Rhodococcus equi challenge.
  • The study suggests that the Congo red staining proteins are not essential for developing protective immunity against R. equi.