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Neurodevelopmental outcomes of infants of diabetic mothers

Shu-Ming Shao1, Hong-Rong Tian

  • 1Department of Pediatrics, Peking University People's Hospital, Beijing 100044, China (Zhang X-R, Email: icy.zhang@ 163. com).

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|September 18, 2021
PubMed

Insights

Infants of diabetic mothers (IDMs) face increasing risks. This review explores their sensory, motor, language, and intellectual neurodevelopmental outcomes, highlighting areas needing more research.

Area of Science:

  • Developmental Neuroscience
  • Pediatric Endocrinology
  • Maternal-Fetal Medicine

Background:

  • Rising incidence of pre-pregnancy diabetes mellitus and gestational diabetes mellitus.
  • Increasing number of infants of diabetic mothers (IDMs) annually.
  • IDMs are linked to adverse perinatal outcomes and potential neurodevelopmental impacts.

Purpose of the Study:

  • To review and summarize the neurodevelopmental outcomes of infants of diabetic mothers (IDMs).
  • To consolidate existing literature on IDM neurodevelopmental trajectories.
  • To provide a reference for clinical practice concerning IDMs.

Main Methods:

  • Comprehensive literature review of studies on IDM neurodevelopmental outcomes.
  • Synthesis of findings across sensory, perception, motor, and language domains.
  • Analysis of intellectual development, neuropsychiatric disorders, and neurological examination findings.

Main Results:

  • IDMs exhibit potential negative impacts across various neurodevelopmental aspects.
  • Literature on IDM neurodevelopmental outcomes remains relatively limited.
  • Specific areas reviewed include sensory, motor, language, intellectual, and neuropsychiatric development.

Conclusions:

  • IDMs represent a growing population with potential neurodevelopmental challenges.
  • Further research is crucial to fully understand and address the neurodevelopmental sequelae in IDMs.
  • This review serves as a foundational reference for clinicians managing infants of diabetic mothers.

Keywords:
Diabetic motherInfantNeurodevelopmentOutcome

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