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[Complications induced by general anesthetics].

M Drouet1, A Sabbah, J Le Sellin

  • 1Laboratoire d'Immuno-Allergologie, C.H.R., Angers.

Allergie Et Immunologie
|March 1, 1986
PubMed
Summary

Anesthesia adverse reactions were observed in 38 patients over one year. Female patients and elevated total IgE levels were frequently associated with these allergic reactions, particularly to Thiopental, Suxamethonium, and Fentanyl.

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Area of Science:

  • Anesthesiology
  • Immunology
  • Clinical Pharmacology

Background:

  • Adverse reactions during anesthesia pose significant risks.
  • Identifying causative agents and patient risk factors is crucial for patient safety.
  • Allergic reactions are a subset of adverse events requiring specific diagnostic approaches.

Purpose of the Study:

  • To analyze parameters associated with adverse reactions during anesthesia.
  • To evaluate the diagnostic utility of skin tests (ST) and Lymphoblastic Transformation Test (L.T.T.) in identifying drug-induced allergies.
  • To report findings on Thiopental, Suxamethonium, and Fentanyl.

Main Methods:

  • Retrospective analysis of 38 adverse reaction cases over one year.
  • Data collection included patient demographics (sex, age, atopy) and reaction details.
  • Diagnostic procedures involved skin tests (Prick-test, intra-dermal test) and L.T.T. for specific anesthetic drugs.

Main Results:

  • A high frequency of reactions (81.5%) was observed in female patients.
  • Elevated total IgE levels (≥150 Ul/ml) were present in 38% of cases.
  • Concordant positive ST and L.T.T. suggested likely allergic reactions, while concordant negatives suggested non-allergic origins.

Conclusions:

  • Female sex and elevated total IgE are potential risk factors for anesthesia-related adverse reactions.
  • Combined use of ST and L.T.T. aids in diagnosing drug allergies during anesthesia.
  • Discordant results between ST and L.T.T. warrant caution and avoidance of the implicated drug.

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