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Updated: Oct 19, 2025

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Published on: March 26, 2019
Does the venous pressure theory of multiple sclerosis pathophysiology deserve a second chance?
Grant Alexander Bateman1, Jeannette Lechner-Scott2, Michael Fionn Carey3
1Department of Medical Imaging, John Hunter Hospital, Locked Bag 1, Newcastle Region Mail Center, Newcastle, NSW 2310, Australia; Newcastle University Faculty of Health, Callaghan Campus, Newcastle, NSW, Australia.
Abstract:
The theory that multiple sclerosis is related to venous pressure has been discredited due to previous operator dependent diagnostic criteria and premature attempts at treatment. (1) An elevation in venous pressure may only be a component of the compliance changes found in MS. (2) The neck veins may only supply a component of the venous pressure elevation found intracranially. Although a more targeted approach towards neck angioplasty (both towards disease subtype and those with more favorable stenoses) may be beneficial, we would advocate caution. We encourage others to give the venous pressure theory a second chance and to replicate our work.
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