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Updated: Oct 19, 2025
06:35
Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
Published on: April 27, 2016
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ASSESSMENT OF ENDOTHELIAL DYSFUNCTION IN PREGNANT WOMEN WITH OBESITY AND PREECLAMPSIA
Marta M Zelinka-Khobzey1, Kostiantyn V Tarasenko1, Tetiana V Mamontova1
1POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE.
Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|September 19, 2021
Summary
In pregnant women with obesity and preeclampsia, vascular endothelial growth factor (VEGF) levels decrease while circulating endothelial microparticles increase, indicating endothelial dysfunction.
Area of Science:
- Reproductive medicine and maternal health.
- Cardiovascular research.
Background:
- Obesity and preeclampsia are significant risk factors for adverse pregnancy outcomes.
- Endothelial dysfunction plays a crucial role in the pathophysiology of preeclampsia.
- Biomarkers are needed to assess endothelial function in high-risk pregnancies.
Purpose of the Study:
- To evaluate serum vascular endothelial growth factor (VEGF) levels.
- To quantify circulating endothelial microparticles (CD32+CD40+) in peripheral blood.
- To correlate these markers with obesity severity and preeclampsia in pregnant women.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) for serum VEGF.
- Flow cytometry for CD32+CD40+ circulating endothelial microparticles.
- Study included 122 pregnant women stratified by BMI and preeclampsia status.
Main Results:
- Serum VEGF concentration decreased with increasing obesity severity and preeclampsia.
- Circulating CD32+CD40+ endothelial microparticles increased in pregnant women with obesity and preeclampsia.
- This inverse pattern suggests endothelial dysfunction in this population.
Conclusions:
- Serum VEGF and CD32+CD40+ microparticles are potential reliable markers.
- These markers can help assess the severity of endothelial dysfunction.
- Useful for managing pregnant women with obesity and preeclampsia.
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