CHARACTERISTICS OF CD68+ AND CD163+ EXPRESSION IN PLACENTA OF WOMEN WITH PREECLAMPSIA AND OBESITY
Marta M Zelinka-Khobzey1, Kostiantyn V Tarasenko1, Tetiana V Mamontova1
1POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE.
Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|November 2, 2021
Summary
Obesity and preeclampsia in pregnant women are linked to an imbalance of placental macrophages, with a higher expression of pro-inflammatory CD68+ macrophages. This suggests a potential cause for preeclampsia development.
Area of Science:
- Immunology
- Obstetrics
- Pathology
Background:
- Preeclampsia is a serious pregnancy complication.
- Obesity is a known risk factor for preeclampsia.
- Placental macrophages play a crucial role in pregnancy.
Purpose of the Study:
- To investigate the expression of CD68+ and CD163+ macrophages in placentas of women with obesity and preeclampsia.
- To understand the role of macrophage polarization in the development of preeclampsia.
Main Methods:
- Immunohistochemical analysis of placental tissues.
- Study included 20 placentas from women divided into four groups: normal weight, class II obesity, normal weight with preeclampsia, and class II obesity with preeclampsia.
Main Results:
- A predominance of pro-inflammatory CD68+ macrophages over anti-inflammatory CD163+ macrophages was observed in all groups.
- Women with both obesity and preeclampsia showed significantly higher CD68+ macrophage expression in placental villi stroma compared to controls.
- A shift towards CD163+ macrophage polarization was noted in Kashchenko-Hofbauer cells across all groups.
Conclusions:
- Imbalance in placental macrophage polarization, favoring pro-inflammatory types, may contribute to preeclampsia development.
- These findings highlight the potential role of macrophage dysfunction in the pathophysiology of preeclampsia in obese women.
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