PATHOGENETIC ROLE OF MACROPHAGE COLONY-STIMULATING FACTOR (CSF-1) IN PREDICTING ENDOMETRIOID DISEASE

Area of Science:

• Gynecology
• Reproductive Medicine
• Biomarker Discovery

Background:

• Endometrioid disease, a chronic inflammatory condition, affects women of reproductive age.
• Current diagnostic methods for endometriosis can be invasive and lack prognostic specificity.
• Identifying reliable biomarkers is crucial for early diagnosis and management.

Purpose of the Study:

• To quantify Colony-stimulating factor 1 (CSF-1) levels in peritoneal fluid and menstrual blood of women with endometrioid disease.
• To evaluate the diagnostic and prognostic value of CSF-1 in endometrioid disease.

Main Methods:

• The study included 80 women of child-bearing age, divided into a study group (n=50) with confirmed endometrioid disease and a control group (n=30) without endometriosis.
• CSF-1 levels were measured in peritoneal fluid and menstrual blood samples from both groups.

Main Results:

• Significantly higher CSF-1 levels were observed in the peritoneal fluid of women with endometrioid disease compared to controls (p=0.029).
• Menstrual blood also showed significantly increased CSF-1 levels in the study group (p=0.00004).
• A trend towards increased CSF-1 was noted with more severe stages of endometriosis and adhesions.

Conclusions:

• CSF-1 levels are significantly elevated in both peritoneal fluid (1.2-fold) and menstrual blood (1.4-fold) in women with endometrioid disease.
• CSF-1 demonstrates potential as a diagnostic and prognostic biomarker for assessing endometrioid disease progression.