Alternative Cosmetic and Medical Applications of Injectable Deoxycholic Acid: A Systematic Review.

Area of Science:

• Dermatology
• Aesthetic Medicine
• Minimally Invasive Procedures

Background:

• Injectable deoxycholic acid (DCA) is increasingly used for minimally invasive lipolysis.
• Its application extends beyond submental fat reduction to various cosmetic concerns.

Purpose of the Study:

• To systematically review and evaluate the evidence for off-label applications of injectable DCA.
• To assess the efficacy and treatment regimens of DCA in diverse cosmetic uses.

Main Methods:

• Comprehensive literature search across major databases (MEDLINE, Embase, CINAHL, Web of Science, CENTRAL).
• Inclusion of studies reporting DCA applications, treatment protocols, and patient outcomes.
• Calculation of overall success rates based on reported improvements.

Main Results:

• Eleven studies confirmed DCA's cosmetic use for excess adipose tissue in multiple body areas, with over 85% success rates.
• Eight case reports demonstrated DCA's efficacy in treating lipomas, xanthelasmas, and other conditions.
• High preliminary efficacy was observed, but study quality varied.

Conclusions:

• Injectable DCA is a versatile tool for minimally invasive lipolysis across various anatomical sites.
• Further high-level research with standardized protocols is essential for definitive recommendations on off-label DCA use.