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Evaluation of Risk Factors for Bleeding After Ultrasound-Guided Liver Biopsy
Haoyu Jing1, Zhanxiong Yi1, Enhui He1
1Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People's Republic of China.
Insights
Age, number of needle passes, and platelet count are key predictors of bleeding risk after ultrasound-guided liver biopsies. Younger patients and those with more needle passes or low platelets face higher bleeding complication risks.
Area of Science:
- Hepatology
- Interventional Radiology
- Patient Safety
Background:
- Ultrasound-guided percutaneous liver biopsy is a common diagnostic procedure.
- Hemorrhagic complications are a significant concern, impacting patient outcomes and healthcare costs.
Purpose of the Study:
- To identify independent risk factors for post-procedure bleeding after ultrasound-guided liver biopsies.
- To enhance patient safety by predicting and mitigating bleeding risks.
Main Methods:
- Retrospective review of 1193 ultrasound-guided percutaneous liver biopsies.
- Analysis of patient demographics, biopsy details, laboratory findings, and complications.
- Statistical analysis including univariate and multivariable regression.
Main Results:
- Age under 18 years, low platelet count, and increased needle passes were independent predictors of bleeding.
- While international normalized ratio and prothrombin time showed association, they lacked predictive value.
- Sex and focal liver lesions did not influence bleeding risk.
Conclusions:
- Age, platelet count, and number of needle passes are reliable predictors of bleeding complications.
- These factors can guide pre-procedural risk assessment and patient management.
- Optimizing biopsy techniques and patient selection can minimize hemorrhagic risks.
Purpose:
This study was performed to analyze the risk factors for hemorrhagic complications after ultrasound-guided liver biopsies.
Patients And Methods:
In this retrospective study, we reviewed 1193 ultrasound-guided percutaneous liver biopsies performed in our hospital from January 2018 to December 2020. Relevant patient characteristics, indications for biopsy, laboratory findings, biopsy technique, hemorrhagic complications, and pathologic outcomes were collected.
Results:
We analyzed 834 procedures performed on 807 patients with complete data. The bleeding group comprised 45 patients with post-procedure bleeding, and non-bleeding group comprising the remaining 789 patients. Univariate analysis showed that age (p < 0.001), number of needle passes (p = 0.009), platelet count (p = 0.002), prothrombin time (p < 0.001), and international normalized ratio (p < 0.001) were associated with post-procedure bleeding. Multivariable regression analysis showed that age under 18 years (p < 0.001), low platelet count (p = 0.001), and increased needle passes (p = 0.025) were independent risk factors for bleeding complications.
Conclusion:
Sex and focal liver lesions did not affect the risk of post-procedure bleeding. The international normalized ratio and prothrombin time were associated with an increased incidence of bleeding; however, they had no predictive value. Age, number of needle passes, and platelet count were identified as reliable predictors of bleeding.
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