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Complication and Sequelae of COVID-19: What Should We Pay Attention to in the Post-Epidemic Era

Keda Yang1, Guangfu Wen2, Jinpeng Wang1

  • 1Department of Orthopedics, First Hospital of China Medical University, Shenyang, China.

Frontiers in Immunology
|September 20, 2021
PubMed

Insights

COVID-19 causes organ complications and sequelae beyond respiratory issues by triggering autoimmune responses via ACE2 intervention. Understanding these long-term effects is crucial for patient recovery and global health strategies.

Area of Science:

  • Virology
  • Immunology
  • Cardiovascular Research

Background:

  • COVID-19 pandemic significantly impacts global health and daily life.
  • Patients experience multi-organ complications and sequelae beyond initial respiratory symptoms.
  • Long-term effects require focused attention in the post-epidemic era.

Purpose of the Study:

  • Systematically analyze COVID-19 complications and sequelae across eight major organ systems.
  • Investigate the role of Angiotensin-Converting Enzyme 2 (ACE2) intervention in the Renin-Angiotensin System (RAS) axis.
  • Elucidate the autoimmune mechanisms underlying COVID-19-related organ damage.

Main Methods:

  • Comprehensive literature review of over 1000 articles published in 2020.
  • Systematic analysis of COVID-19 complications and sequelae.
  • Focus on organ damage mediated by ACE2 and the RAS pathway.

Main Results:

  • COVID-19 infection leads to multi-system organ complications and sequelae.
  • The Renin-Angiotensin System (RAS) regulatory axis, particularly ACE2, is implicated in disease pathology.
  • Autoimmune responses triggered by SARS-CoV-2 (2019-nCoV) contribute to tissue and organ damage.

Conclusions:

  • COVID-19-induced autoimmune responses are a key factor in organ damage.
  • Understanding ACE2 intervention in the RAS axis is vital for managing COVID-19 sequelae.
  • This research aids healthcare professionals in addressing the complex complications of COVID-19.

Keywords:
COVID-19Web of Sciencebibliometric analysiscomplicationeight systemssequelae

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