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Related Concept Videos

Oral Hypoglycemic Agents: Glinides01:06

Oral Hypoglycemic Agents: Glinides

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Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
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Acute Pancreatitis II: Clinical Manifestations and Management01:30

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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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Dipeptidyl Peptidase 4 Inhibitors01:23

Dipeptidyl Peptidase 4 Inhibitors

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Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
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Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
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Glucagon-like Receptor Agonists01:24

Glucagon-like Receptor Agonists

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Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
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Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Related Experiment Video

Updated: Oct 19, 2025

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
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Repaglinide-Induced Acute Pancreatitis.

Ndausung Udongwo1, Anton Mararenko1, Halah Alchalabi1

  • 1Internal Medicine, Jersey Shore University Medical Center, Neptune, USA.

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|September 20, 2021
PubMed
Summary

Repaglinide, a diabetes medication, can cause acute pancreatitis. This case highlights the importance of considering drug-induced causes for pancreatitis, even with normal triglyceride levels.

Keywords:
acute pancreatitisalcoholgallstonesmedication-induced pancreatitisrepaglinide

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Area of Science:

  • Gastroenterology
  • Endocrinology
  • Pharmacology

Background:

  • Acute pancreatitis is a significant cause of hospitalization with high morbidity and mortality.
  • Common causes include alcohol, gallstones, hypertriglyceridemia, and medication side effects.
  • Guideline-directed medical therapy is crucial for appropriate management.

Observation:

  • An 84-year-old male presented with acute pancreatitis.
  • The patient had normal triglyceride levels and no significant alcohol use.
  • Repaglinide, a medication for diabetes mellitus, was identified as the likely cause.

Findings:

  • Diagnosis was confirmed through imaging, physical examination, and laboratory markers.
  • Symptoms resolved upon discontinuation of repaglinide.
  • This case suggests repaglinide as a potential cause of acute pancreatitis.

Implications:

  • Raises awareness of repaglinide-induced acute pancreatitis.
  • Highlights the need to consider medication side effects in pancreatitis etiology.
  • Emphasizes thorough patient history and medication review for diagnosis.