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Excess Body Weight and Pancreatic Disease
Mats L Wiese1, Ali A Aghdassi1, Markus M Lerch1
1Department of Medicine A, University Medicine Greifswald, Greifswald, Germany.
Visceral Medicine
|September 20, 2021
Summary
Excess body weight (EBW) is a risk factor for acute pancreatitis and pancreatic cancer, increasing incidence and worsening outcomes. The role of EBW in chronic pancreatitis is less clear, warranting further research.
Area of Science:
- Gastroenterology and Hepatology
- Metabolic and Endocrine Disorders
- Oncology
Background:
- Excess body weight (EBW) is a known risk factor for numerous health conditions.
- The
Purpose of the Study:
- To examine the role of excess body weight (EBW) in the incidence and outcomes of pancreatitis and pancreatic cancer.
- To discuss the concept of the
Main Methods:
- Literature review and synthesis of existing studies on EBW, acute pancreatitis (AP), chronic pancreatitis (CP), and pancreatic cancer (PC).
- Analysis of findings considering different methodologies for assessing EBW, including fat distribution.
Main Results:
- EBW, particularly visceral obesity, is a significant risk factor for increased incidence and poorer outcomes in AP and PC.
- The association between EBW and CP outcomes is less conclusive, with some studies suggesting a potential protective effect of higher body mass.
- Current evidence is insufficient to confirm an obesity paradox in CP, possibly due to confounding factors and varied assessment methods.
Conclusions:
- EBW is linked to higher incidence and adverse outcomes in AP and PC.
- The impact of EBW on CP requires further investigation.
- Maintaining a normal weight is recommended throughout the disease continuum of pancreatitis and pancreatic cancer.
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