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Updated: Oct 19, 2025

Isolating Nasal Olfactory Stem Cells from Rodents or Humans
Published on: August 22, 2011
Primary Olfactory Ensheathing Cell Culture from Human Olfactory Mucosa Specimen
Mansoureh Hashemi1, Mahmoudreza Hadjighassem2,3
1Functional neurosurgery research center, Shahid Beheshti University of medical sciences, Tehran, Iran.
Abstract:
The human olfactory mucosa is located in the middle and superior turbinates, and the septum of nasal cavity. Olfactory mucosa plays an important role in detection of odours and it is also the only nervous tissue that is exposed to the external environment. This property leads to easy access to the olfactory mucosa for achieving various researches. The lamina propria of olfactory mucosa consists of olfactory ensheathing cells (OECs) that cover the nerve fibers of olfactory. Here we describe a protocol for isolation of OECs from biopsy of human olfactory mucosa.
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