PhenClust, a standalone tool for identifying trends within sets of biological phenotypes using semantic similarity...

We sought to cluster biological phenotypes using semantic similarity and create an easy-to-install, stable, and reproducible tool.

We generated Phenotype Clustering (PhenClust)-a novel application of semantic similarity for interpreting biological phenotype associations-using the Unified Medical Language System (UMLS) metathesaurus, demonstrated the tool's application, and developed Docker containers with stable installations of two UMLS versions.

PhenClust identified disease clusters for drug network-associated phenotypes and a meta-analysis of drug target candidates. The Dockerized containers eliminated the requirement that the user install the UMLS metathesaurus.

Clustering phenotypes summarized all phenotypes associated with a drug network and two drug candidates. Docker containers can support dissemination and reproducibility of tools that are otherwise limited due to insufficient software support.

PhenClust can improve interpretation of high-throughput biological analyses where many phenotypes are associated with a query and the Dockerized PhenClust achieved our objective of decreasing installation complexity.