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Intravascular large B-cell lymphoma affecting multiple cranial nerves: A histopathological study
Andrea Porzionato1, Guido Pelletti2, Luisa Barzon3
1Section of Human Anatomy, Department of Neuroscience, University of Padova, Padova, Italy.
Neuropathology : Official Journal of the Japanese Society of Neuropathology
|September 20, 2021
Summary
Intravascular large B-cell lymphoma (IVLBCL) is a rare cancer affecting blood vessels. This case highlights its rapid progression and widespread neurological impact, emphasizing the need for early diagnosis.
Area of Science:
- Neuropathology
- Hematologic Oncology
- Vascular Biology
Background:
- Intravascular large B-cell lymphoma (IVLBCL) is a rare hematologic malignancy with a poor prognosis.
- It is characterized by malignant lymphocytes proliferating within small and medium-sized blood vessels.
Observation:
- A 54-year-old male presented with symptoms leading to a postmortem diagnosis of intracerebral IVLBCL.
- The autopsy revealed widespread ischemic lesions and IVLBCL involvement in cerebral hemispheres, cerebellum, brainstem nuclei, and cranial nerve trunks.
Findings:
- Histopathological examination identified malignant B-cells occluding vessels in multiple brain regions, including cranial nerve nuclei and trunks.
- Specific cranial nerve involvement correlated with clinical signs such as diplopia and dysphonia.
Implications:
- This case provides novel insights into the radiological, anatomical, and clinical correlations of IVLBCL.
- Integrated neuroradiological, neurological, and neuropathological approaches are crucial for early identification of this challenging disease.
