Light therapy improved depression-like behavior induced by chronic unpredictable mild stress in Mongolian gerbils

Progress has been made in elucidating the mechanism by which light modulates depressive-like behaviors. However, almost all of these studies ignore an important issue, namely, that examining the effects of light therapy in nocturnal animals may be difficult because the influences of light on behavioral responses differ between nocturnal and diurnal animals. To date, few diurnal rodents have been utilized to establish animal models that closely mimic clinical depression. Herein, the chronic unpredictable mild stress model, which is the most representative, reliable, and effective rodent model of depression, was implemented in diurnal Mongolian gerbils for the first time. The gerbils were subjected to two hours of light therapy or fluoxetine treatment for 2 weeks. Our work revealed that Mongolian gerbils subjected to chronic unpredictable mild stress showed depression-like behaviors. Interestingly, we also found that light therapy improved anhedonic behavior more effectively than fluoxetine after two weeks of treatment. In summary, our study is the first to use diurnal Mongolian gerbils, which have the same circadian rhythm as humans, to establish an effective, economical, and practical animal model of depression and confirmed that light therapy could improve depression-like behavior more effectively than fluoxetine to some extent in diurnal Mongolian gerbils, which establishes a good foundation for clarifying the neural mechanism of light therapy for depression.