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Updated: Oct 19, 2025
Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
Published on: November 10, 2023
[Pathology and Immunology of COVID-19]
1Department of Pathology, National Institute of Infectious Diseases.
Abstract:
Since the first case of COVID-19 was reported from Wuhan, China in December 2019, SARS-CoV-2 has been spreading globally and has become major public health concern. At present, development of specific treatment for COVID-19 is in progress and several countermeasures have been subjected to clinical trials. However, efficacy of these countermeasures is limited. For development of effective medicines or vaccines against infectious diseases, it is mandatory to elucidate its etiology and pathogenesis by means of pathological analysis. Pathological studies revealed that the COVID-19 mainly affects respiratory tracts although other organs are also involved. In addition, immunological studies demonstrated that host immune response may exacerbates COVID-19 through systemic inflammation. In this review, we would like to overview pathology and immunology of COVID-19.
Insights
This review overviews the pathology and immunology of COVID-19, caused by SARS-CoV-2. Understanding the disease
Area of Science:
- Pathology
- Immunology
- Infectious Diseases
Context:
- The global spread of SARS-CoV-2 (COVID-19) presents a significant public health challenge.
- Current treatments and countermeasures show limited efficacy.
- Understanding disease etiology and pathogenesis is crucial for developing effective interventions.
Purpose:
- To provide a comprehensive overview of the pathology and immunology of COVID-19.
- To synthesize current knowledge on how SARS-CoV-2 affects the body and elicits immune responses.
Summary:
- COVID-19 primarily impacts the respiratory system but also affects other organs.
- Host immune responses can exacerbate COVID-19 through systemic inflammation.
- Pathological and immunological insights are essential for advancing treatment and vaccine development.
Impact:
- Informs the development of targeted therapies and vaccines against COVID-19.
- Highlights the complex interplay between the virus and the host immune system.
- Contributes to a deeper understanding of severe acute respiratory syndrome coronavirus 2 pathogenesis.
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