[Prospects for using low-dose radiation in the complex therapy for COVID-19]

Area of Science:

• Radiology
• Immunology
• Molecular Biology

Background:

• COVID-19 treatment remains a challenge, necessitating novel therapeutic approaches.
• Low-dose radiation (LDR) has emerged as a potential therapeutic modality for various conditions.

Purpose of the Study:

• To review existing literature on LDR for COVID-19 treatment.
• To explore LDR's application in other disorders like pneumonia, inflammation, and Alzheimer's disease.
• To elucidate the mechanisms underlying LDR's therapeutic effects.

Main Methods:

• Literature review of studies investigating LDR therapy.
• Analysis of LDR's impact on immune response and oxidative stress.
• Examination of LDR's effects on cytokine activity (e.g., IL-6), gene expression (P53, NF-κB), and ncRNAs.

Main Results:

• LDR demonstrates potential in treating COVID-19, pneumonia, and inflammatory conditions.
• LDR mechanisms involve immune system activation and anti-inflammatory responses.
• LDR influences oxidative stress, cytokine production, gene expression, and ncRNA activity.

Conclusions:

• LDR presents a promising therapeutic strategy for COVID-19 and related inflammatory disorders.
• Further clinical trials with LDR (5-10 cGy) are warranted to establish optimal treatment protocols for COVID-19 patients.
• Understanding LDR's molecular mechanisms can guide the development of effective treatment regimens.