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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Plant-Based Dietary Patterns, Body Composition, Muscle Strength and Function in Middle and Older Age: A Systematic

H Chan1, R V Ribeiro, S Haden

  • 1Hilaria Hin Lam Chan, The University of Sydney, Australia, hilaria720@hotmail.com.

The Journal of Nutrition, Health & Aging
|September 21, 2021
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Summary

Plant-based diets show positive links with body composition in older adults, but their impact on muscle strength needs more research. This review analyzed studies on diet and musculoskeletal health.

Keywords:
Plant-based dietary patternbody compositionelderlymiddle-agedmuscle

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Area of Science:

  • Gerontology
  • Nutritional Science
  • Musculoskeletal Health

Background:

  • Sarcopenia, a condition affecting muscle mass and strength, is common in middle-aged and older adults.
  • Plant-based diets are increasingly recognized for their potential influence on body composition and musculoskeletal health.

Purpose of the Study:

  • To systematically review the effects of plant-based dietary patterns on body composition, muscle strength, and function.
  • To synthesize evidence for middle-aged and older adults following plant-based diets.

Main Methods:

  • A comprehensive systematic search was conducted across multiple databases (MEDLINE, Embase, Scopus, etc.) up to March 2019.
  • Included 17 papers (cross-sectional, RCTs, cohort studies) analyzing plant-based diets and musculoskeletal health outcomes.
  • Assessed evidence quality using SIGN and GRADE tools.

Main Results:

  • Plant-based dietary patterns were positively associated with certain body composition metrics.
  • An inverse relationship was observed between plant-based diets and overall body composition.
  • Associations with muscle strength and function remained inconclusive.

Conclusions:

  • Plant-based diets may influence body composition in older adults, but evidence is mixed.
  • Further high-quality research is required to clarify the impact of plant-based diets on muscle strength and function.
  • Understanding these relationships is crucial for promoting healthy aging and preventing sarcopenia.