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Fluorescent Nanoparticles for the Measurement of Ion Concentration in Biological Systems

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Cubosome Based Ion-Selective Optodes-Toward Tunable Biocompatible Sensors.

Emilia Stelmach¹, Ewa Nazaruk¹, Krzysztof Maksymiuk¹

¹Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.

Analytical Chemistry

|September 21, 2021

Summary

New optical ion-selective sensors utilize cubosomes or hexosomes, offering biocompatibility and tunable performance. Temperature changes internal structure, altering analyte access and response patterns for advanced nanoprobes.

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Area of Science:

Nanotechnology
Analytical Chemistry
Materials Science

Background:

Conventional polymeric optical nanoprobes face limitations in stability and performance.
Nanostructural lipid liquid phases offer potential for advanced sensor development.

Purpose of the Study:

To introduce a new generation of optical ion-selective sensors based on cubosomes and hexosomes.
To evaluate the performance and characteristics of these novel nanostructural optodes.

Main Methods:

Utilizing cubosomes and hexosomes as nanostructural lipid liquid phases for optode fabrication.
Investigating the effect of temperature on the internal structure and analyte access of the lipid nanoparticles.
Analyzing the response patterns of the cubosome/hexosome optodes to analytes.

Main Results:

Cubosome and hexosome optodes demonstrate biocompatibility, self-assembly preparation, and high stability in solution.
The internal structure of these lipid nanoparticles is reversibly altered by temperature.
This structural change influences analyte access and modifies the sensor's response pattern, offering tunable analytical performance.

Conclusions:

Cubosome and hexosome optodes represent a highly promising alternative to traditional polymeric optical nanoprobes.
Their unique temperature-triggered mechanism provides enhanced control over sensor performance.
These nanostructural lipid-based sensors offer significant advantages for various analytical applications.