Orodispersible films: Conception to quality by design

Area of Science:

• Pharmaceutical Technology
• Drug Delivery Systems
• Patient-Centric Formulations

Background:

• Orodispersible films (ODFs) are innovative, ultra-thin dosage forms designed for oral administration without water.
• They address challenges in swallowing and improve medication adherence, particularly for pediatric and geriatric patients with conditions like dysphagia or Parkinson's disease.

Purpose of the Study:

• To review the conception, evolution, and technological advancements of ODFs.
• To explore the potential of ODFs in delivering various therapeutic agents, including drugs, herbal extracts, probiotics, and vaccines.
• To discuss key strategies in ODF development, such as drug loading, taste masking, and stability enhancement.

Main Methods:

• Literature review focusing on the development and application of ODFs.
• Analysis of strategies for optimizing drug delivery and patient compliance with ODFs.
• Overview of Quality by Design (QbD) principles in ODF formulation.

Main Results:

• ODFs represent a significant advancement in patient-centric pharmaceutical design, offering convenience and improved compliance.
• The technology supports the delivery of a wide range of active substances, broadening therapeutic possibilities.
• Effective strategies exist for overcoming challenges like taste masking and ensuring drug stability within ODFs.

Conclusions:

• ODFs are a versatile and promising drug delivery platform with substantial potential for various patient populations and therapeutic applications.
• Further development, guided by QbD principles, can optimize ODF performance and expand their clinical utility.
• The patient-centric nature of ODFs positions them for significant growth in the pharmaceutical market.