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Related Concept Videos

In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

30
Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
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In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

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Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients,...
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Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

Biopharmaceutical Factors Influencing Drug Product Design: Overview

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Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though...
41

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Related Experiment Video

Updated: Oct 19, 2025

Methods for the Self-integration of Megamolecular Biopolymers on the Drying Air-LC Interface
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Innovative Drying Technologies for Biopharmaceuticals.

Ashutosh Sharma1, Dikshitkumar Khamar2, Sean Cullen3

  • 1Pharmaceutical and Molecular Biotechnology Research Centre (PMBRC), Waterford Institute of Technology, Main Campus, Cork Road, Waterford X91K0EK, Ireland.

International Journal of Pharmaceutics
|September 21, 2021
PubMed
Summary
This summary is machine-generated.

Innovative drying technologies offer a cost-effective alternative to traditional freeze-drying for biopharmaceutical manufacturing. These methods promise reduced production cycles, lower energy use, and enhanced scalability for parenteral products.

Keywords:
BiopharmaceuticalsCharacterization TechniquesDrying TechnologiesFormulationProcess Analytical Technology

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Area of Science:

  • Biopharmaceutical Manufacturing
  • Drug Delivery Systems
  • Process Engineering

Background:

  • Biopharmaceuticals have significantly improved patient outcomes for various diseases.
  • Current batch freeze-drying methods are costly due to long cycles, high energy use, and substantial capital investment.
  • Reducing manufacturing costs is crucial for meeting the growing demand for biopharmaceuticals without compromising quality.

Purpose of the Study:

  • To review innovative drying technologies for parenteral biopharmaceutical manufacturing.
  • To explore alternatives to traditional, costly freeze-drying processes.
  • To identify technologies that can reduce manufacturing costs and improve efficiency.

Main Methods:

  • Compilation and review of emerging drying technologies.
  • Analysis of technologies enabling continuous manufacturing (e.g., Spin-freeze-drying, Spray-drying, Lynfinity® Technology).
  • Evaluation of technologies for controlled particle characteristics (e.g., PRINT® Technology, Microglassification™).

Main Results:

  • Several innovative drying technologies present alternatives to batch freeze-drying.
  • Technologies like Spin-freeze-drying and Spray-drying support continuous manufacturing.
  • PRINT® Technology and Microglassification™ enable control over dry particle attributes.
  • Some technologies offer easier scale-up and reduced validation requirements.
  • Integration of Process Analytical Technology (PAT) enhances process understanding.

Conclusions:

  • Innovative drying technologies can significantly reduce biopharmaceutical manufacturing costs.
  • These technologies offer potential for increased manufacturing capacity and efficiency.
  • Adoption of new drying methods, coupled with PAT, can lead to more economical production of high-quality biopharmaceuticals.