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Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
Published on: November 3, 2023
Acute Kidney Injury and Acute Respiratory Distress Syndrome
1Division of Pulmonary Sciences and Critical Care Medicine, Department of Internal Medicine, University of Colorado, Anschutz Medical Campus, 12700 East 19th Avenue, Box C272, Aurora, CO 80045, USA.
Abstract:
Acute kidney injury (AKI) complicates approximately a third of all acute respiratory distress syndrome (ARDS) cases, and the combination of the two drastically worsens prognosis. Recent advances in ARDS supportive care have led to improved outcomes; however, much less is known on how to prevent and support patients with AKI and ARDS together. Understanding the dynamic relationship between the kidneys and lungs is crucial for the practicing intensivist to prevent injury. This article summarizes key concepts for the critical care physician managing a patient with ARDS complicated by AKI. Also provided is a discussion of AKI in the COVID-19 era.
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