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Will the Digital Mass Filter Be the Next High-Resolution High-Mass Analyzer?
Peter T A Reilly1, Sumeet Chakravorty1, Conner F Bailey1
1Department of Chemistry, Washington State University, Pullman, Washington 99164, United States.
Journal of the American Society for Mass Spectrometry
|September 22, 2021
Summary
Digital mass filters offer superior resolution and sensitivity across an unlimited mass range. Unlike sine-driven instruments, they avoid stability zone limitations, enabling broader applications in mass spectrometry.
Area of Science:
- Analytical Chemistry
- Mass Spectrometry Instrumentation
Background:
- Higher stability zones in mass filters improve resolution but limit mass range and increase fringe field effects in sine-driven instruments.
- Digitally driven mass filters overcome these limitations by maintaining constant AC voltage and zero DC voltage, unaffected by stability zone changes.
Purpose of the Study:
- To catalogue accessible stability zones for digitally driven mass filters using new waveform generation technology.
- To theoretically evaluate the performance of digital mass filters across various stability zones.
Main Methods:
- Cataloguing 12 accessible stability zones for digital mass filters.
- Theoretical analysis of resolving power and pseudopotential well depths across these zones.
Main Results:
- Theoretical resolving powers range from 22 to 1,300,000.
- Pseudopotential well depths range from 3.5 to 43 V, significantly deeper than standard sine filters.
- Aligned axial stability wells in higher zones maximize well depth, enhancing ion transmission and sensitivity.
Conclusions:
- Digital mass filters can achieve high resolution and high sensitivity.
- These filters offer an essentially unlimited mass range, overcoming limitations of traditional sine-driven instruments.
Keywords:
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