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Kombucha ameliorates LPS-induced sepsis in a mouse model
Penghui Wang1, Zhihua Feng2,1, Xiao Sang1
1College of Life Science, Fujian Normal University, Fuzhou, Fujian Province 350117, PR China. minhe214@fjnu.edu.cn.
Food & Function
|September 22, 2021
Summary
Kombucha demonstrated significant anti-inflammatory effects in mice, improving survival rates and gut health during sepsis. This study highlights kombucha
Area of Science:
- Microbiology
- Immunology
- Gastroenterology
Background:
- Kombucha is a fermented tea with known health benefits.
- The anti-inflammatory mechanisms of kombucha require further scientific investigation.
- Sepsis involves a severe inflammatory response with high mortality.
Purpose of the Study:
- To investigate the protective effects of kombucha against lipopolysaccharide (LPS)-induced sepsis in mice.
- To analyze the impact of kombucha on intestinal microecology and immune function during sepsis.
Main Methods:
- Mice were treated with kombucha and subsequently challenged with LPS.
- Kombucha composition was analyzed for key compounds like organic acids and polyphenols.
- Immune markers (TNF-α, IL-1β, IL-6), immune cell levels, NF-κB signaling, and gut microbiota were assessed.
Main Results:
- Kombucha increased survival rates from 0% to 40% in LPS-treated mice.
- It reduced pro-inflammatory cytokines and restored T cell and macrophage levels.
- Kombucha modulated gut microbiota diversity, promoting beneficial butyrate-producing bacteria.
Conclusions:
- Kombucha exhibits significant anti-inflammatory and immunomodulatory effects in a sepsis model.
- It prevents immune dysfunction and alleviates sepsis-induced damage.
- Kombucha shows potential as a novel therapeutic agent for sepsis and related inflammatory conditions.
