Discovery Proteomics for COVID-19: Where We Are Now

Area of Science:

• Proteomics
• Immunology
• Infectious Diseases

Background:

• Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the COVID-19 pandemic.
• COVID-19 has had a significant global societal impact.

Purpose of the Study:

• To summarize proteomic research on hallmark proteins in COVID-19.
• To elucidate proteins relevant for short- and long-term diagnosis and prognosis.
• To review the humoral response and autoimmunity risk in COVID-19.

Main Methods:

• Literature review of proteomic studies related to COVID-19.
• Analysis of research on viral proteins and host immune responses.

Main Results:

• Proteomic research has identified key proteins associated with COVID-19.
• These proteins are crucial for understanding disease diagnosis and prognosis.
• COVID-19 is linked to a variable humoral immune response and an elevated risk of autoimmunity.

Conclusions:

• Proteomics offers valuable insights into COVID-19 pathogenesis and clinical management.
• Understanding the immune response is critical for managing long-term health consequences, including autoimmunity.