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Updated: Oct 19, 2025
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Published on: March 17, 2023
Thienylpiperidine Donor NIR Xanthene-Based Dye for Photoacoustic Imaging
Chathuranga S L Rathnamalala1, Nicholas W Pino2, Bailey S Herring1
1Department of Chemistry, Mississippi State University, Mississippi State, Mississippi 39762, United States.
Abstract:
Few xanthene-based near-infrared (NIR) photoacoustic (PA) dyes with absorbance >800 nm exist. As accessibility to these dyes requires long and tedious synthetic steps, we designed a NIR dye (XanthCR-880) with thienylpiperidine donors and a xanthene acceptor that is accessible in 3-4 synthetic steps. The dye boasts a strong PA signal at 880 nm with good biological compatibility and photostability, yields multiplexed imaging with an aza-BODIPY reference dye, and is detected at a depth of 4 cm.
