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Bee venom ameliorates cardiac dysfunction in diabetic hyperlipidemic rats
Faten Zahran1, Alaa Mohamad1, Nabila Zein1
1Biochemistry Division, Chemistry Department, Faculty of Science, Zagazig University, Zagazig 44519, Egypt.
Experimental Biology and Medicine (Maywood, N.J.)
|September 22, 2021
Summary
Bee venom effectively treats cardiac dysfunction in diabetic rats by lowering blood glucose and lipids. It also reduces oxidative stress and inflammation, similar to metformin and atorvastatin therapy.
Area of Science:
- Cardiovascular Research
- Pharmacology
- Toxicology
Background:
- High blood glucose and lipid levels are significant risk factors for heart disease.
- Bee venom possesses known hypoglycemic, hypolipidemic, anti-inflammatory, and antioxidant properties.
Purpose of the Study:
- To investigate the effects of bee venom on cardiac dysfunction in diabetic hyperlipidemic rats.
- To compare bee venom's efficacy against a combined therapy of metformin and atorvastatin.
Main Methods:
- Induction of type 2 diabetes and hyperlipidemia in male albino rats using nicotinamide and streptozotocin, followed by a high-fat diet.
- Treatment groups included negative control, positive control, bee venom (two doses), and combined metformin/atorvastatin therapy.
- Analysis of blood parameters, cardiac biomarkers, oxidative stress markers, and gene expression in heart tissue.
Main Results:
- Bee venom and combined therapy significantly reduced glucose, lipids, cardiac enzymes (troponin I, CK, LDH), and oxidative stress markers (MDA, NF-κβ).
- Both treatments increased insulin, HDL cholesterol, and total antioxidant capacity.
- Bee venom attenuated cardiac dysfunction by reducing oxidative stress and downregulating the NF-κβ signaling pathway.
Conclusions:
- Bee venom demonstrates significant cardioprotective effects in a model of diabetic hyperlipidemia.
- Bee venom offers a potential therapeutic alternative for managing cardiac dysfunction associated with diabetes and hyperlipidemia.
