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First fluconazole-resistant Candida auris isolated from fungal otitis in Iran

Mojtaba Taghizadeh Armaki1, Saeid Mahdavi Omran1, Keyvan Kiakojuri2

  • 1Department of Medical Mycology and Parasitology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

Current Medical Mycology
|September 23, 2021
PubMed
Abstract

Insights

This study reports the first case of fluconazole-resistant Candida auris otitis in an immunocompetent patient in Iran. Topical antifungals successfully treated the infection without recurrence.

Area of Science:

  • Medical Mycology
  • Infectious Diseases

Background:

  • Candida auris is an emerging pathogenic yeast known for global spread and multidrug resistance.
  • This species can cause hospital-acquired infections and survive harsh environments.
  • Conventional diagnostic methods often misidentify Candida auris.

Purpose of the Study:

  • To document the first case of fluconazole-resistant Candida auris otitis in an immunocompetent individual in Iran.
  • To highlight the clinical and microbiological characteristics of this resistant isolate.

Main Methods:

  • Case report describing a patient with C. auris otitis.
  • Antifungal susceptibility testing, including determination of minimum inhibitory concentration (MIC) for fluconazole.
  • Clinical management and follow-up of the patient.

Main Results:

  • The C. auris isolate exhibited fluconazole resistance with an MIC of ≥ 32 μg/ml.
  • The patient was successfully treated with topical clotrimazole and miconazole.
  • No recurrence of otitis was observed post-treatment.

Conclusions:

  • This case represents the second fluconazole-resistant C. auris strain identified from otitis in Iran.
  • The findings underscore the emergence of antifungal resistance in C. auris infections.
  • Topical antifungal therapy can be effective in managing C. auris otitis, even with fluconazole resistance.
Keywords:
Candida aurisFluconazole-resistantIran

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