Related Experiment Video
Updated: Oct 19, 2025
08:22
Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model
Published on: June 20, 2025
194
[Infections and inflammation in the development of stroke].
E M Samoilova1, G M Yusubalieva1, V V Belopasov2
1Federal Scientific and Clinical Center of Specialized Types of Medical Care and Medical Technologies of the Federal Medical and Biological Agency of Russia, Moscow, Russia.
Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|September 23, 2021
Summary
Infections and systemic inflammation significantly increase stroke risk by triggering pro-inflammatory responses and impacting cerebrovascular health. Recognizing this link is crucial for preventing stroke complications in infectious patients.
Area of Science:
- Neurology
- Immunology
- Infectious Diseases
Background:
- Infectious diseases and systemic inflammation are increasingly recognized as critical factors in stroke pathogenesis.
- Pro-inflammatory reactions play a significant role in cerebrovascular pathology and stroke development.
Purpose of the Study:
- To systematically review the role of infections and systemic inflammation in stroke development.
- To analyze various risk factors contributing to stroke pathogenesis via pro-inflammatory pathways.
Main Methods:
- Systematic review of existing data.
- Analysis of interactions between systemic inflammation, hemostasis, endothelial damage, and immune responses.
- Examination of infectious processes as trigger and risk factors for stroke.
Main Results:
- Infections and systemic inflammation contribute to stroke risk through multiple mechanisms, including hemostasis disturbances, clot formation, and endothelial damage.
- Specific focus on cerebrovascular disease mechanisms post-COVID-19.
- Identification of acute, medium-term, and long-term effects of infections on stroke risk.
Conclusions:
- Understanding the link between infection and stroke is vital for preventive strategies.
- Early identification and management of infection-related stroke risk can reduce cerebrovascular complications.
- Interventions in drug therapy and rehabilitation are key for infectious patients at risk of stroke.
Related Concept Videos
01:38Inflammation
56.2K
Overview
56.2K
01:27Regulation of Stroke Volume
4.2K
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
4.2K
01:23Atherosclerosis IV: Nursing Management
98
Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
98
01:30Atherosclerosis I: Introduction
185
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
185
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
1.1K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.1K
01:26Coronary Artery Disease II: Pathophysiology
90
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
90