Understanding environmental epigenomics in autism spectrum disorder: an interview with Farah R Zahir

Area of Science:

• Neurogenomics
• Neuroepigenomics
• Genetics

Background:

• Dr. Farah R. Zahir specializes in identifying genetic and epigenetic causes of neurodevelopmental diseases.
• Her research has led to the characterization of new intellectual disability (ID) syndromes and the discovery of causative genes.
• She has utilized whole-genome sequencing and advanced bioinformatics for comprehensive analysis of ID causes.

Discussion:

• The interview highlights Dr. Zahir's significant contributions to understanding epigenomics in relation to autism and intellectual disability.
• Her work includes the discovery of Zahir Friedman syndrome, linked to a major epigenomic regulator.
• She discusses the potential of harnessing epigenomic modifications for therapeutic interventions.

Key Insights:

• Identification of novel genetic and epigenetic factors contributing to neurodevelopmental disorders.
• Establishment of Zahir Friedman syndrome, an ID/autism spectrum disorder caused by an epigenomic regulator.
• Pioneering use of whole-genome sequencing and bioinformatics in ID research.

Outlook:

• Investigating the influence of environmental factors on epigenomics for neurodevelopmental disorders.
• Exploring the potential of epigenomic modifications for prophylaxis and therapeutics.
• Continued research at UBC's Department of Medical Genetics to advance neurogenomics and neuroepigenomics.