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Updated: Oct 19, 2025
07:06
Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
Published on: December 8, 2014
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The Italian National Faecal Microbiota Transplantation Program: a coordinated effort against Clostridioides difficile
Maria Chiara de Stefano1, Benedetta Mazzanti1, Francesca Vespasiano1
1Centro Nazionale Trapianti, Istituto Superiore di Sanità, Rome, Italy.
Annali Dell'Istituto Superiore Di Sanita
|September 23, 2021
Summary
Recurrent Clostridioides difficile infection (rCDI) is challenging to treat. The Italian National FMT Program offers a promising alternative therapy for rCDI, showing progress even during the COVID-19 pandemic.
Area of Science:
- Gastroenterology and Infectious Diseases
- Microbiome Therapeutics
Background:
- Clostridioides difficile infection (CDI) causes antibiotic-associated diarrhea, with high recurrence rates.
- Recurrent CDI (rCDI) presents a significant healthcare burden, often inadequately managed by conventional antibiotics.
Purpose of the Study:
- To outline the characteristics and progress of the Italian National FMT Program for adults with rCDI.
- To assess the program's performance and adaptability during the COVID-19 pandemic.
Main Methods:
- The Italian National FMT Program was established in 2018 to standardize fecal microbiota transplantation (FMT) for rCDI.
- Data collection and analysis focused on program implementation and outcomes amidst the pandemic.
Main Results:
- Fecal microbiota transplantation (FMT) has emerged as a successful alternative therapy for rCDI.
- The Italian National FMT Program demonstrated resilience and continued operation during the COVID-19 pandemic.
Conclusions:
- The Italian National FMT Program provides a high-quality standard for FMT in treating rCDI.
- FMT represents a viable and effective therapeutic strategy for recurrent C. difficile infection, even under challenging global health circumstances.
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