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Related Concept Videos

Hypertension II: Pathophysiology01:29

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Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
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Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
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Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
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Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
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Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
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Related Experiment Video

Updated: Oct 19, 2025

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
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Soluble Klotho and Incident Hypertension.

David A Drew1, Ronit Katz2, Stephen Kritchevsky3

  • 1Division of Nephrology, Tufts Medical Center, Boston, Massachusetts.

Clinical Journal of the American Society of Nephrology : CJASN
|September 24, 2021
PubMed
Summary

Higher klotho levels are linked to increased diastolic blood pressure but a lower risk of developing hypertension and slower blood pressure increases over time in older adults.

Keywords:
blood pressurehypertensionklothosystolic blood pressure

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Area of Science:

  • Gerontology
  • Cardiovascular Medicine
  • Endocrinology

Background:

  • Hypertension poses significant health risks despite available treatments.
  • Soluble klotho, a circulating protein, shows protective effects against hypertension in preclinical models.
  • Human studies on klotho and blood pressure are limited.

Purpose of the Study:

  • To investigate the association between serum klotho levels and blood pressure in older adults.
  • To examine the relationship between klotho and prevalent, incident, and longitudinal blood pressure trajectories.
  • To adjust for various demographic, clinical, and metabolic factors in the analysis.

Main Methods:

  • Serum klotho was measured in the Health, Aging, and Body Composition Study cohort.
  • Cross-sectional and longitudinal associations between klotho and blood pressure metrics were evaluated.
  • Analyses accounted for demographics, cardiovascular/kidney disease risk factors, and mineral metabolism markers.

Main Results:

  • Higher klotho was associated with higher baseline diastolic blood pressure (BP) but not systolic BP.
  • Elevated klotho levels correlated with a reduced risk of incident hypertension.
  • Higher klotho was linked to slower annual increases in both systolic and diastolic BP during follow-up.

Conclusions:

  • Increased serum klotho is associated with higher baseline diastolic BP.
  • Higher klotho levels predict a lower incidence of hypertension.
  • Klotho may play a role in modulating blood pressure trajectories in older adults.