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Isothiazolopyrimidines--new group of anticancer agents. II
Z Machoń1, I Mielczarek, J Wieczorek
1Department of Organic Chemistry, Medical Academy, Wrocław.
Archivum Immunologiae Et Therapiae Experimentalis
|January 1, 1987
Abstract:
In reactions of 5-aminoisothiazolopyrimidines 1 with glycosilisothiocyanates and phenyl isocyano- or isocyanates, N-glycosilo-N-phenylo- and N-isothiazolopyrimidinothiocarbamides type II were obtained. The same compound--5-aminoisothiazolopyrimidine 1 in reaction with glucose, arabinose and ribose bromoderivatives was converted into N-glycosiloaminoisothiazolopyrimidies type 3. Some of the newly synthetized compounds appeared effective against L-1210 leukemia and Sa-180 sarcoma.