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Multiple Cardiovascular Diseases or Risk Factors Increase the Severity of Coronavirus Disease 2019

Tomoyuki Yamada1,2, Taku Ogawa1,3, Kenta Minami1

  • 1Infection Control Center, Osaka Medical and Pharmaceutical University Hospital.

Circulation Journal : Official Journal of the Japanese Circulation Society
|September 24, 2021
PubMed

Insights

Patients with coronavirus disease 2019 (COVID-19) and multiple cardiovascular diseases and risk factors (CVDRFs) face a higher risk of acute respiratory distress syndrome. However, in-hospital death risk did not significantly differ between patients with single or multiple CVDRFs.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pulmonology

Background:

  • Coronavirus disease 2019 (COVID-19) is a global health concern.
  • Cardiovascular diseases and risk factors (CVDRFs) are common comorbidities.
  • The impact of multiple CVDRFs on COVID-19 severity requires further investigation.

Purpose of the Study:

  • To investigate if COVID-19 disease severity differs between patients with single versus multiple CVDRFs.
  • To analyze the association between the number of CVDRFs and adverse COVID-19 outcomes.

Main Methods:

  • Retrospective cohort study design.
  • Inclusion of COVID-19 patients with single (n=281) or multiple (n=412) CVDRFs.
  • Multivariable logistic regression analysis to assess outcomes.

Main Results:

  • No significant difference in in-hospital death risk between groups.
  • Significantly higher risk of acute respiratory distress syndrome in patients with multiple CVDRFs (OR: 1.75, 95% CI: 1.09-2.81).

Conclusions:

  • COVID-19 patients with multiple CVDRFs exhibit an elevated risk of complications, specifically acute respiratory distress syndrome.
  • The number of CVDRFs is a critical factor in predicting COVID-19 severity and complications.
Abstract

Keywords:
Cardiovascular diseaseCardiovascular risk factorsCoronavirus disease

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