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Updated: Oct 19, 2025

Imaging and Quantification of the Area of Fast-Moving Microbubbles Using a High-Speed Camera and Image Analysis
Published on: September 5, 2020
The Bubble Eye Sign: Understanding the Radiological Imaging of Gas inside the Orbit
1Department of Ophthalmology, Memorial Ophthalmic Centre, Tung Wah Eastern Hospital, Hong Kong.
The "Bubble Eye sign" on X-ray indicates retained intraocular gas after retinal surgery, not orbital fracture. This finding prompts further ophthalmological evaluation, avoiding unnecessary CT scans.
Area of Science:
- Ophthalmology
- Radiology
- Medical Imaging
Background:
- Intraocular gas, radiolucent on X-ray, is typically absent in the orbit.
- Retained intravitreal gas is used for tamponade during intraocular surgeries.
- Post-surgical falls are common due to altered stereopsis and patient positioning.
Purpose of the Study:
- To describe the "Bubble Eye sign" on skull X-ray.
- To differentiate intravitreal gas from orbital emphysema.
- To guide appropriate diagnostic pathways for patients with suspected orbital injury post-retinal surgery.
Main Methods:
- Analysis of characteristic radiographic findings on skull X-ray.
- Distinguishing features of intravitreal gas versus orbital emphysema.
- Clinical correlation with patient history and surgical interventions.
Main Results:
- Intravitreal gas presents as a distinct bubble outlining the globe on X-ray.
- Orbital emphysema appears as a superiorly located crescent or concave shape.
- The "Bubble Eye sign" reliably indicates iatrogenic intravitreal gas.
Conclusions:
- The "Bubble Eye sign" is a crucial indicator of retained intravitreal gas post-retinal surgery.
- Radiographic identification of this sign necessitates ophthalmological assessment.
- This avoids unnecessary radiation exposure from computed tomography scans for orbital fracture evaluation.
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