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Meningovascular Syphilis Presenting as a Brain Mass in an Immunocompetent Male
Khanh Pham1, Lee Gottesdiener1, Matthew S Simon1,2
1New York-Presbyterian Hospital, Weill Cornell Medical Center, New York, New York, USA.
Open Forum Infectious Diseases
|September 24, 2021
Abstract:
We present a case of a human immunodeficiency virus-negative man with syphilitic meningovascular disease with subjacent involvement of brain parenchyma leading to a mass-forming inflammatory lesion that was pathologically distinct from a typical gumma. Syphilis was diagnosed after tissue obtained from a brain biopsy demonstrated spirochetes consistent with Treponema pallidum and confirmed by 16S ribosomal RNA sequencing.

